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Two people have been killed and scores have been injured after three blasts on the Underground network and another on a double-decker bus in London. UK Prime Minister Tony Blair said it was "reasonably clear" there had been a series of terrorist attacks.
He said it was "particularly barbaric" that it was timed to coincide with the G8 summit. He is returning to London.
An Islamist website has posted a statement - purportedly from al-Qaeda - claiming it was behind the attacks.
Home Secretary Charles Clarke said blasts occurred between Aldgate East and Liverpool Street tube stations; between Russell Square and King's Cross tube stations; at Edgware Road tube station; and on a bus at Tavistock Square.
The Queen said she was "deeply shocked" and sent her sympathy to those affected.
Paul Woodrow of the London Ambulance Service is in Russell Square near the bus which exploded.
"At King's Cross station there is a rescue operation in the tunnel down on the line," he said.
"Although we cannot confirm casualties - it is too early - we are dealing with large numbers of casualties, and we believe there are a number of casualties."
London's police chief Sir Ian Blair said there had been "many casualties" but it was too early to give a precise figure.
More than 182 casualties and and one of the dead were taken to the Royal London Hospital in Whitechapel but it said that 123 people had since been released.
And St Mary's Hospital said it was dealing with 26 injured people, including four with critical injuries and eight in a serious condition.
Sir Ian urged people to stay where they were and not to call emergency services unless it was a life-threatening situation.
He reassured the public that an emergency plan was in place and the situation was "steadily coming under control".
London Mayor Ken Livingstone, speaking from Singapore before flying back to the UK, said Londoners would not be divided by a "cowardly attack."
He said it was an "indiscriminate" attempt at slaughter with no consideration for age or religion. All London Underground services have been suspended indefinitely and bus services in central London (Zone One) have been halted.
Early reports had suggested a power surge could be to blame for explosions on the Underground but this was later discounted.
Describing the bus blast in Tavistock Square, eyewitness Belinda Seabrook said she saw an explosion rip through the bus.
"I was on the bus in front and heard an incredible bang, I turned round and half the double-decker bus was in the air," she said.
She said the bus was travelling from Euston to Russell Square and had been "packed" with people turned away from Tube stops.
"It was a massive explosion and there were papers and half a bus flying through the air, I think it was the number 205," she said.
"There must be a lot of people dead as all the buses were packed, they had been turning people away from the Tube stops."
One caller to BBC Five said his friend had seen "the bus ripped open like a can of sardines and bodies everywhere".
Loyita Worley, who works for a City law firm, said she was on the underground train when an explosion took place in the next carriage, while it was in a tunnel.
The 49-year-old said: "All the lights went out and the train came to an immediate halt. There was smoke everywhere and everyone was coughing and choking, but remained calm. We couldn't open the doors."
Once the doors were opened they were taken along to Liverpool Street station.
She said the carriage where an explosion happened was "black on the inside" and she saw people who appeared to have their clothes blown off.
Name: Cath Home: Sheffield, United Kingdom About Me: A baby will make love stronger, days shorter, nights longer, bankroll smaller, home happier, clothes shabbier, the past forgotten, and the future worth living for. See my complete profile
When I heard about this I thought of you. I hope all is well and nobody you knew were injured.